36
1.
Gariano RF, Gardner TW. Retinal angiogenesis in development
and disease. Nature 2005; 438 (7070): 960-6.
2.
Cunha-Vaz JG. The blood-retinal barriers system. Basic concepts
and clinical evaluation. Exp Eye Res 2004; 78 (3): 715-21.
3.
Rizzolo LJ. Development and role of tight junctions in the retinal
pigment epithelium. Int Rev Cytol 2007; 258: 195-234.
4.
Friedman E, Ts’o MO. The retinal pigment epithelium. II. His-
tologic changes associated with age. Arch Ophthalmol 1968; 79
(3): 315-20.
5.
Gass JDM. Stereoscopic atlas of macular diseases: diagnosis and
treatment. 4th ed. St Louis: Mosby; 1997.
6.
de Jong PT. Age-related macular degeneration. N Engl J Med
2006; 355 (14): 1474–85.
7.
Jaeger EA, Anderson DR, Glaser JS, et al. Duane’s ophthalmol-
ogy on CD-ROM edition. Philadelphia: Lippincott Williams &
Wilkins, 2006: Chapter1.
8.
Huang JD, Presley JB, Chimento MF, Curcio CA, Johnson M.
Age-related Changes in Human Macular Bruch’s Membrane
as seen by Quick-Freeze/Deep-Etch. Exp Eye Res 2007; 85 (2):
202–218.
9.
Hayreh SS. Segmental nature of the choroidal vasculature. Br J
Ophthalmol 1975; 59 (11): 631-48.
10.
Ramrattan RS, van der Schaft TL, Mooy CM, de Bruijn WC,
Mulder PG, de Jong PT. Morphometric analysis of Bruch’s mem-
brane, the choriocapillaris, and the choroid in aging. Invest Oph-
thalmol Vis Sci 1994; 35 (6): 2857-64.
11.
Starita C, Hussain AA, Pagliarini S, Marshall J. Hydrodynamics of
ageing Bruch’s membrane: implications for macular disease. Exp
Eye Res 1996; 62 (5): 565-72.
12.
Gilmore AP. Anoikis. Cell Death Differ 2005; 12 (Suppl. 2):
1473-1477.
13.
Penfold PL, Liew SC, Madigan MC, Provis JM. Modulation of
major histocompatibility complex class II expression in retinas
with age-related macular degeneration. Invest Ophthalmol Vis Sci
1997; 38 (10): 2125-2133.
14.
Guymer RH, Bird AC, Hageman GS. Cytoarchitecture of choroi-
dal capillary endothelial cells. Invest Ophthalmol Vis Sci 2004; 45
(6): 1660-1666.
15.
Feeney-Burns L, Burns RP, Gao CL. Age-related macular changes
in humans over 90 years old. Am J Ophthalmol 1990; 109 (3):
265-278.
16.
Feeney-Burns L, Hilderbrand ES, Eldridge S. Aging human RPE:
morphometric analysis of macular, equatorial, and peripheral cells.
Invest Ophthalmol Vis Sci 1984; 25 (2): 195-200.
17.
Feeney L. Lipofuscin and melanin of human retinal pigment epi-
thelium. Fluorescence, enzyme cytochemical, and ultrastructural
studies. Invest Ophthalmol Vis Sci 1978; 17 (7): 583-600.
18.
Sparrow JR, Boulton M. RPE lipofuscin and its role in retinal
pathobiology. Exp Eye Res 2005; 80 (5): 595-606.
19.
Coleman HR, Chan CC, Ferris FL, III, Chew EY. Age-related
macular degeneration. Lancet 2008; 372 (9652): 1835-1845.
References:
20.
Tabandeh H, Dubovy S, Green WR. Bilateral midperipheral large
drusen and retinal pigment epithelial detachments associated with
multifocal areas of choroidal neovascularization: a histopathologic
study. Retina 2006; 26 (9): 1063-1069.
21.
Sarks S, Cherepanoff S, Killingsworth M, Sarks J. Relationship
of Basal laminar deposit and membranous debris to the clinical
presentation of early age-related macular degeneration. Invest
Ophthalmol Vis Sci 2007; 48 (3): 968-977.
22.
van der Schaft TL, Mooy CM, de Bruijn WC, Oron FG, Mulder
PG, de Jong PT. Histologic features of the early stages of age-re-
lated macular degeneration. A statistical analysis. Ophthalmology
1992; 99 (2): 278-286.
23.
Curcio CA, Millican CL. Basal linear deposit and large drusen
are specific for early age-related maculopathy. Arch Ophthalmol
1999; 117 (3): 329-339.
24.
Ding X, Patel M, Chan CC. Molecular pathology of age-related
macular degeneration. Prog Retin Eye Res 2009; 28 (1): 1-18.
25.
Hageman GS, Luthert PJ, Victor Chong NH, Johnson LV, An-
derson DH, Mullins RF. An integrated hypothesis that considers
drusen as biomarkers of immune-mediated processes at the RPE-
Bruch’s membrane interface in aging and age-related macular de-
generation. Prog Retin Eye Res 2001; 20 (6): 705-732.
26.
Crabb JW, Miyagi M, Gu X, Shadrach K, West KA, Sakaguchi H,
Kamei M, Hasan A, Yan L, Rayborn ME, Salomon RG, Hollyfield
JG. Drusen proteome analysis: an approach to the etiology of age-
related macular degeneration. Proc Natl Acad Sci USA 2002; 99
(23): 14682-14687.
27.
Umeda S, Suzuki MT, Okamoto H, Ono F, Mizota A, Terao K,
Yoshikawa Y, Tanaka Y, Iwata T. Molecular composition of drusen
and possible involvement of anti-retinal autoimmunity in two
different forms of macular degeneration in cynomolgus monkey
(Macaca fascicularis). FASEB J 2005; 19 (12): 1683-1685.
28.
Wang J, Ohno-Matsui K, Yoshida T, Shimada N, Ichinose S, Sato
T, Mochizuki M, Morita I. Amyloid-beta up-regulates comple-
ment factor B in retinal pigment epithelial cells through cytokines
released from recruited macrophages/microglia: Another mecha-
nism of complement activation in age-related macular degenera-
tion. J Cell Physiol 2009; 220 (1): 119-128.
29.
Gass JD. Pathogenesis of disciform detachment of the neuroepi-
thelium. Am J Ophthalmol 1967; 63 (3 Suppl.): 1-139.
30.
Bird AC, Bressler NM, Bressler SB, Chisholm IH, Coscas G,
Davis MD, de Jong PT, Klaver CC, Klein BE, Klein R. An inter-
national classification and grading system for age-related macu-
lopathy and age-related macular degeneration. The International
ARM Epidemiological Study Group. Surv Ophthalmol 1995; 39
(5): 367-374.
31.
Klein R, Klein BE, Jensen SC, Meuer SM. The five-year incidence
and progression of age-related maculopathy: the Beaver Dam Eye
Study. Ophthalmology 1997; 104 (1): 7-21.
32.
Yannuzzi LA, Guyer DR, Green WR. The retina atlas. Saint-Louis,
USA. Mosby. 1998; 782 p.
33.
Bressler NM, Silva JC, Bressler SB, Fine SL, Green WR. Clin-
icopathologic correlation of drusen and retinal pigment epithelial
abnormalities in age-related macular degeneration. Retina 1994;
14 (2): 130-142.
