98
measurement of intrinsic fluorescence and reflectance of
the ocular fundus. Appl Opt 1994; 33 (31): 7439-52.
17. Delori FC, Dorey CK, Staurenghi G, Arend O, Goger DG,
Weiter JJ. In vivo fluorescence of the ocular fundus exhibits
retinal pigment epithelium lipofuscin characteristics. Invest
Ophthalmol Vis Sci 1995; 36 (3): 718-29.
18. Webb RH, Hughes GW, Delori FC. Confocal scanning
laser ophthalmoscope. Appl Opt 1987; 26 (8): 1492-99.
19. Bellmann C, Holz FG, Schapp O, Volcker HE, Otto TP.
Topographie der Fundusautofluoreszenz mit einem neuen
konfokalen Scanning-Laser-Ophthalmoskop. Ophthal-
mologe 1997; 94 (6): 385-91.
20. von Ruckmann A., Fitzke FW, Bird AC. Distribution of
fundus autofluorescence with a scanning laser ophthalmo-
scope. Br J Ophthalmol 1995; 79 (5): 407-12.
21. American Nationale Standards Institute (ANSI). Ameri-
can National Standard for the Safe Use of Lasers. ANSI
Z136.1-2007. American Nationale Standards Institute
(ANSI). Washington, USA. 2007.
22. Solbach U, Keilhauer C, Knabben H, Wolf S. Imaging of
retinal autofluorescence in patients with age-related macu-
lar degeneration. Retina 1997; 17 (5): 385-89.
23. Bellmann C, Rubin GS, Kabanarou SA, Bird AC, Fitzke
FW. Fundus autofluorescence imaging compared with dif-
ferent confocal scanning laser ophthalmoscopes. Br J Oph-
thalmol 2003; 87 (11): 1381-86.
24. Spaide RF. Fundus autofluorescence and age-related macu-
lar degeneration. Ophthalmology 2003; 110 (2): 392-9.
25. Delori FC, Goger DG, Dorey CK. Age-related accumula-
tion and spatial distribution of lipofuscin in RPE of normal
subjects. Invest Ophthalmol Vis Sci 2001; 42 (8): 1855-66.
26. Delori FC, Fleckner MR, Goger DG, Weiter JJ, Dorey
CK. Autofluorescence distribution associated with drusen
in age-related macular degeneration. Invest Ophthalmol
Vis Sci 2000; 41 (2): 496-504.
27. Spaide RF. Autofluorescence imaging with the fundus cam-
era. In: Holz FG, Schmitz-Valckenberg S, Spaide RF, Bird
AC, eds. Atlas of autofluorescence imaging. Berlin, Ger-
many. Springer. 2007; 5: 49-54.
28. Wabbels B, Demmler A, Paunescu K, Wegscheider E, Pre-
ising MN, Lorenz B. Fundus autofluorescence in children
and teenagers with hereditary retinal diseases. Graefes Arch
Clin Exp Ophthalmol 2006; 244 (1): 36-45.
29. Weiter JJ, Delori FC, Wing GL, Fitch KA. Retinal pigment
epithelial lipofuscin and melanin and choroidal melanin in
human eyes. Invest Ophthalmol Vis Sci 1986; 27 (2): 145-
52.
30. Lois N, Halfyard AS, Bunce C, Bird AC, Fitzke FW. Re-
producibility of fundus autofluorescence measurements
obtained using a confocal scanning laser ophthalmoscope.
Br J Ophthalmol 1999; 83 (3): 276-9.
31. Lois N, Halfyard AS, Bird AC, Fitzke FW. Quantitative
evaluation of fundus autofluorescence imaged “in vivo” in
eyes with retinal disease. Br J Ophthalmol 2000; 84 (7):
741-5.
32. Lois N, Owens SL, Coco R, Hopkins J, Fitzke FW, Bird
AC. Fundus autofluorescence in patients with age-related
macular degeneration and high risk of visual loss. Am J
Ophthalmol 2002; 133 (3): 341-9.
33. Spital G, Radermacher M, Muller C, Brumm G, Lom-
matzsch A, Pauleikhoff D. Autofluoreszenz-Charakteris-
tika von Lipofuszinbestandteilen bei unterschiedlichen
Formen der späten altersabhängigen Makuladegeneration.
Klin Monatsbl Augenheilkd 1998; 213 (1): 23-31.
34. von Ruckmann A., Fitzke FW, Bird AC. Fundus autofluo-
rescence in age-related macular disease imaged with a la-
ser scanning ophthalmoscope. Invest Ophthalmol Vis Sci
1997; 38 (2): 478-86.
35. von Ruckmann A., Schmidt KG, Fitzke FW, Bird AC,
Jacobi KW. Dynamik der Einlagerung und des Abtrans-
portes von Lipofuszin im retinalen Pigmentepithel bei al-
tersbedingter Makuladegeneration. Klin Monatsbl Augen-
heilkd 1998; 213 (1): 32-7.
36. von Ruckmann A., Fitzke FW, Bird AC. Distribution of
pigment epithelium autofluorescence in retinal disease
state recorded in vivo and its change over time. Graefes
Arch Clin Exp Ophthalmol 1999; 237 (1): 1-9.
37. Schmitz-Valckenberg S, Jorzik J, Unnebrink K, Holz FG.
Analysis of digital scanning laser ophthalmoscopy fundus
autofluorescence images of geographic atrophy in advanced
age-related macular degeneration. Graefes Arch Clin Exp
Ophthalmol 2002; 240 (2): 73-8.
38. Bindewald A, Bird AC, Dandekar SS, Dolar-Szczasny J,
Dreyhaupt J, Fitzke FW, Einbock W, Holz FG, Jorzik JJ,
Keilhauer C, Lois N, Mlynski J, Pauleikhoff D, Staurenghi
G, Wolf S. Classification of fundus autofluorescence pat-
terns in early age-related macular disease. Invest Ophthal-
mol Vis Sci 2005; 46 (9): 3309-14.
39. Sawa M, Ober MD, Spaide RF. Autofluorescence and reti-
nal pigment epithelial atrophy after subretinal hemorrhage.
Retina 2006; 26 (1): 119-20.
40. Smith RT, Chan JK, Busuoic M, Sivagnanavel V, Bird
AC, Chong NV. Autofluorescence characteristics of early,
atrophic, and high-risk fellow eyes in age-related macular
degeneration. Invest Ophthalmol Vis Sci 2006; 47 (12):
5495-504.
41. Sarks JP, Sarks SH, Killingsworth MC. Evolution of geo-
graphic atrophy of the retinal pigment epithelium. Eye
1988; 2 (Pt 5) 552-77.
42. Sarks SH. Ageing and degeneration in the macular region:
a clinico-pathological study. Br J Ophthalmol 1976; 60
(5): 324-41.
43. Deckert A, Schmitz-Valckenberg S, Jorzik J, Bindewald
A, Holz FG, Mansmann U. Automated analysis of digital
fundus autofluorescence images of geographic atrophy in
advanced age-related macular degeneration using confocal
scanning laser ophthalmoscopy (cSLO). BMC Ophthal-
mol 2005; 5 (1): 8.
44. Dreyhaupt J, Mansmann U, Pritsch M, Dolar-Szczasny J,
Bindewald A, Holz FG. Modelling the natural history of
geographic atrophy in patients with age-related macular
degeneration. Ophthalmic Epidemiol 2005; 12 (6): 353-
62.
45. Sunness JS, Gonzalez-Baron J, Applegate CA, Bressler
NM, Tian Y, Hawkins B, Barron Y, Bergman A. Enlarge-
ment of atrophy and visual acuity loss in the geographic
